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CME on Transplantation is dedicated to online CME conferences, courses and presentations (slides with voice over) on transplantation, given by local and international experts. Its mission is to keep you up-to-date with the most recent developments on transplantation.
 Presentation
"Steroid Minimization Protocols"
Dr. Edward H. Cole (biography)
English - 2004-02-02 - 37 minutes
(58 slides)

Summary :
In this presentation Dr Cole presents the latest data available on steroid minimization protocols, in a discussion about their associated risks and benefits; in which patients they may be utilised; and whether steroid avoidance (a short steroid course of 0 to 7 days) is preferable to later steroid withdrawal.

Randomized trials have shown an increase in acute rejection rates with steroid withdrawal (1, 2), although other protocols might achieve better results. Short-term data show steroid avoidance to be safe and effective in low immunologic risk patients, and as having other clinical benefits which will be discussed here.

Copyright © 2004 E-MedHosting.com Inc

Learning objectives :
The participant will learn about steroid minimization protocols:

Benefits of Steroid Minimization
Steroid Withdrawal versus Avoidance:
- Risks vs benefits
-->Acute rejection
-->Renal function
-->Graft and patient survival
-->Freedom from adverse events
Conclusions
Outstanding Issues

Bibliographic references :
1. Vanrenterghem, Yves; Lebranchu, Yvon; Hené, Ronald; Oppenheimer, Frederico; Ekberg, Henrik; Steroid Dosing Study Group. DOUBLE-BLIND COMPARISON OF TWO CORTICOSTEROID REGIMENS PLUS MYCOPHENOLATE MOFETIL AND CYCLOSPORINE FOR PREVENTION OF ACUTE RENAL ALLOGRAFT REJECTION. “” Transplantation: Volume 70(9) 15 November 2000 pp 1352-1359


2. Ahsan N, Hricik D, Matas A, Rose S, Tomlanovich S, Wilkinson A, Ewell M, McIntosh M, Stablein D, Hodge E. Prednisone withdrawal in kidney transplant recipients on cyclosporine and mycophenolate mofetil--a prospective randomized study. “ Steroid Withdrawal Study Group.Transplantation.1999 Dec 27;68(12):1865-74.

Others:


Almawi WY, Hess DA, Assi JW, Chudzik DM, Rieder MJ. Pretreatment with glucocorticoids enhances T-cell effector function: possible implication for immune rebound accompanying glucocorticoid withdrawal.
Cell Transplant. 1999 Nov-Dec;8(6):637-47.


Kasiske BL, Chakkera HA, Louis TA, Ma JZ. A meta-analysis of immunosuppression withdrawal trials in renal transplantation. "" J Am Soc Nephrol. 2000 Oct;11(10):1910-7.


Prasad GV, Nash MM, McFarlane PA, Zaltzman JS. Renal transplant recipient attitudes toward steroid use and steroid withdrawal.“”Clin Transplant. 2003 Apr;17(2):135-9.

   


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  Newsletter 1 (2004-04-08)
C-Reactive Protein (CRP)