CME on Transplantation is dedicated to online CME conferences, courses and presentations (slides with voice over) on transplantation, given by local and international experts. Its mission is to keep you up-to-date with the most recent developments on transplantation.
Presentation
"Post-Transplant Diabetes Mellitus - Epidemiology, Treatment, Long-term Effects" Dr. Donald E. Hricik (biography) English - 2004-05-18 - 50 minutes
(38 slides)
Summary : Diabetes Mellitus has emerged as an independent risk factor for cardiovascular events in kidney transplant recipients, with cardiovascular disease being an important cause of death in kidney transplant recipients with functioning grafts. With 30% to 40% of kidney transplant patients being diabetic prior to transplantation and approximately 25% developing post-transplant diabetes mellitus (PTDM) at 3 years, the burden of diabetes on this patient population is quite large indeed.
In this presentation, Dr Hricik explores the epidemiology of diabetes in solid-organ transplant populations. Risk factors for the development of PTDM are presented and the role of different immunosuppressive drugs in the pathogenesis of PTDM in a number of sub-populations is discussed.
Dr. Hricik also discusses the natural history of PTDM as well as its multifaceted management.
Learning objectives : After viewing this presentation, participants will be able to discuss:
o The modifiable and non-modifiable risk factors for the development of PTDM.
o The role of specific immunosuppressive drugs in the pathogenesis of PTDM.
o The therapeutic options available for the treatment of PTDM.
Bibliographic references : Stamler J, Vaccaro O, Neaton JD, Wentworth D. Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial. Diabetes Care. 1993 Feb;16(2):434-44.
Aker S, Ivens K, Grabensee B, Heering P. Cardiovascular risk factors and diseases after renal transplantation. Int Urol Nephrol. 1998;30(6):777-88.
Sumrani NB, Delaney V, Ding ZK, Davis R, Daskalakis P, Friedman EA, Butt KM, Hong JH. Diabetes mellitus after renal transplantation in the cyclosporine era—an analysis of risk factors. Transplantation. 1991 Feb;51(2):343-7.
Hricik DE, Bartucci MR, Moir EJ, Mayes JT, Schulak JA. Effects of steroid withdrawal on posttransplant diabetes mellitus in cyclosporine-treated renal transplant recipients. Transplantation. 1991 Feb;51(2):374-7.
Fabrega AJ, Meslar P, Cohan J, Lash J, Pollak R. Long-term (24-month) follow-up of steroid withdrawal in renal allograft recipients with posttransplant diabetes mellitus. Transplantation. 1995 Dec 27;60(12):1612-4.
Boudreaux JP, McHugh L, Canafax DM, Ascher N, Sutherland DE, Payne W, Simmons RL, Najarian JS, Fryd DS. The impact of cyclosporine and combination immunosuppression on the incidence of posttransplant diabetes in renal allograft recipients. Transplantation. 1987 Sep;44(3):376-81.
