CME on Transplantation is dedicated to online CME conferences, courses and presentations (slides with voice over) on transplantation, given by local and international experts. Its mission is to keep you up-to-date with the most recent developments on transplantation.
Presentation
"Mechanisms of T and B Cell Tolerance" Dr. Anita S. Chong (biography) English - 2004-05-18 - 47 minutes
(27 slides)
Summary : As the demand for transplantation continues to outstrip the available supply of suitable donors, the achievement of sustained, robust allograft accommodation is increasingly important.
In this presentation, Dr. Anita Chong reviews the mechanisms of both T and B cell-mediated tolerance. The concepts of central and peripheral tolerance are introduced and the evidence for the four intrinsic mechanisms of peripheral T cell tolerance is presented.
Dr. Chong also discusses the importance of addressing B cell-mediated tolerance and the potential role of encapsulation strategies in achieving long-term allograft tolerance.
Learning objectives : After viewing this presentation, participants will be able to discuss:
• The definition of tolerance
• Central versus peripheral tolerance
• The four intrinsic mechanisms of peripheral T cell-mediated Tolerance
• B cell-mediated tolerance
• Encapsulation strategies in transplantation
Bibliographic references : Ildstad ST, Sachs DH. Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts. Nature. 1984 Jan 12-18;307(5947):168-70.
Sharabi Y, Sachs DH. Engraftment of allogeneic bone marrow following administration of anti-T cell monoclonal antibodies and low-dose irradiation. Transplant Proc. 1989 Feb;21(1 Pt 1):233-5.
Chan SY, DeBruyne LA, Goodman RE, Eichwald EJ, Bishop DK. In vivo depletion of CD8+ T cells results in Th2 cytokine production and alternate mechanisms of allograft rejection. Transplantation. 1995 Apr 27;59(8):1155-61.
Kang SM, Schneider DB, Lin Z, Hanahan D, Dichek DA, Stock PG, Baekkeskov S. Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction. Nat Med. 1997 Jul;3(7):738-43.
