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CME on Transplantation is dedicated to online CME conferences, courses and presentations (slides with voice over) on transplantation, given by local and international experts. Its mission is to keep you up-to-date with the most recent developments on transplantation.
 Presentation
"Long-term Kidney Transplant Survival Real.. Reality"
Dr. Sundaram Hariharan (biography)
English - 2003-10-09 - 39 minutes
(55 slides)
(7 questions)

Summary :
This presentation will look at clinical outcomes of kidney transplantation and the factors affecting long-term survival. It has been shown that kidney transplant survival has improved in recent years (1), and the possible reasons for this can be manifold. For example, this improvement could be due to immunological factors, better medical management of the patient, and more aggressive diagnostic and biopsy procedures. There may also still be unknown factors that affect long-term survival.

Post-transplant renal function has recently been studied and serum creatinine values were found to be predictive of long-term graft survival in a large cohort of kidney transplant recipients (2). It was also found that renal function has improved in recent years (2). The transplant era has reduced acute rejection and improved renal function, and these factors both affect long-term survival. Immunosuppression has also evolved in recent years to produce new agents, which improve renal function (3).

Copyright © 2003 E-MedHosting.com Inc.

Learning objectives :
The participant will learn about clinical outcomes in kidney transplantation, looking at various factors affecting long-term survival.

Long-term Survival – Conclusion:

Improved
- Era
- Acute Rejection
- Renal Function
- Immunosuppressants

Further Enhancement
- CVS Mortality
- Recurrent Disease
- BKV Nephritis

Limitations
- Organ Supply
- Chronic Allograft Nephropathy

Bibliographic references :
1. Hariharan S, Johnson CP, Bresnahan BA, Taranto SE, McIntosh MJ, Stablein D. Improved graft survival after renal transplantation in the United States, 1988 to 1996.
"" N Engl J Med. 2000 Mar 2;342(9):605-12.


2. Hariharan S, McBride MA, Cherikh WS, Tolleris CB, Bresnahan BA, Johnson CP. Post-transplant renal function in the first year predicts long-term kidney transplant survival.
"" Kidney Int. 2002 Jul;62(1):311-8.


3. Flechner SM, Goldfarb D, Modlin C, Feng J, Krishnamurthi V, Mastroianni B, Savas K, Cook DJ, Novick AC. Kidney transplantation without calcineurin inhibitor drugs: a prospective, randomized trial of sirolimus versus cyclosporine. “” Transplantation. 2002 Oct 27;74(8):1070-6.

   


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