CME on Transplantation is dedicated to online CME conferences, courses and presentations (slides with voice over) on transplantation, given by local and international experts. Its mission is to keep you up-to-date with the most recent developments on transplantation.
Presentation
"Chronic Kidney Disease in Heart, Liver and Lung Transplant Recipients" Dr. Akinlolu O. Ojo (biography) English - 2004-11-26 - 47 minutes
(34 slides)
Summary : The modern immunosuppressive era has resulted in a significantly increased life-expectancy for solid organ transplant recipients. However, as a result of this, combined with the nephrotoxic potential of calcineurin inhibitors (CNI), chronic kidney disease (CKD) is increasingly an increasingly common complication of solid organ transplantation. Here, Dr. Akinlolu Ojo reviews his findings on the incidence of CKD among non-renal transplant recipients in the UNOS transplant registry.
Are certain transplant populations at higher risk of CKD than others? What is the cost of CKD in our transplant patients? What is the contribution of CNI to the risk of CKD post-transplant and how can we alter the immunosuppressive regimen to reduce this risk? Dr. Ojo addresses these questions and more in this superb comprehensive review of one of the most important complications of transplantation today.
Learning objectives : After viewing this presentation, participants will be able to discuss:
• The incidence of chronic kidney disease (CKD) in different solid organ transplant populations
• The financial and morbidity and mortality cost of CKD
• The relative contribution of both pre- and post-transplant factors to the risk of CKD
• The effect of CNI elimination on renal dysfunction and CKD
Bernardini J, Piraino B, Kormos RL. Patient survival with renal replacement therapy in heart transplantation patients. ASAIO J. 1998 Sep-Oct;44(5):M546-8.
English J, Evan A, Houghton DC, Bennett WM. Cyclosporine-induced acute renal dysfunction in the rat. Evidence of arteriolar vasoconstriction with preservation of tubular function. Transplantation. 1987 Jul;44(1):135-41.
